African Collaborative’s Open Application
Issued by: African Collaborative
Focus areas: African-led, founded and based organisation driving bold change
Value: $50 000 to 125 000 annually for three years
Deadline: 17 September 2025
https://tinyurl.com/2e59myda

Good Start Challenge: Sub-Saharan Africa
Issued by: Van Leer Foundation
Focus areas: Innovative solutions that improve the well-being of parents and caregivers of young children in Ethiopia, Kenya, Senegal and Uganda
Value: €50 000 to 200 000
Deadline: 17 September 2025
https://tinyurl.com/4xvspcw3

Socio-economic Impacts of Artificial Intelligence in Africa
Issued by: International Development Research Centre
Focus: Research that explores how AI is reshaping labour markets, productivity and inequality across Africa
Value: CAD1 million per project
Deadline: 17 September 2025
https://tinyurl.com/3bsneun7

Adaptation and Resilience Fund
Issued by: ClimateWorks Foundation
Focus areas: Solutions for urban resilience to extreme heat
Value: Up to US$9 million
Deadline: 19 September 2025
https://tinyurl.com/7v3a8e8n

OST Greenification Program for Startups and SMEs
Deadline: 21 September, 2025.
Apply: https://grantsdatabase.org/category/grants‑for‑startups/

Emerging Climate Champions Award
Issued by: Enlight Foundation and The Patchwork Collective
Focus: Youth-led organisations advancing climate solutions
Value: US$25 million
Deadline: 22 September 2025
https://tinyurl.com/394zp3vy

Strengthening African Policy Research and Regional Collaboration
Issued by: African Think Tank Platform
Focus areas: African think tanks working on economic transformation and governance, climate change, regional trade, food security, human capital and digitalisation
Value: Up to US$10 million
Deadline: 24 September 2025
https://tinyurl.com/2tnrda7k

Nature-based Solutions in Kenya
Issued by: UK PACT
Focus areas: Innovative, capacity-building projects that support Kenya’s just transition ambitions
Value: Not specified
Deadline: 26 September 2025
https://tinyurl.com/33yf39ye

International AIDS Society (IAS) Youth Hub Seed Grant Programme 2026 
Deadline: 29 September 2025, 23:59 CEST
Apply: https://sw.opportunitiesforafricans.com/call-for-applications/international‑aids‑society‑youth‑hub‑seed‑grant‑programme‑2026/

Building Resilience in Agriculture
Issued by: Food for Tomorrow
Focus areas: Innovative projects focused on feasible, nature-positive solutions
Value: Up to US$150 000
Deadline: 30 September 2025
https://tinyurl.com/kku43vfs

Climate and Humanitarian Emergency in Kenya
Issued by: Italian Agency for Development Cooperation
Focus areas: Strengthening community resilience, supporting inclusive development, and addressing the needs of vulnerable populations, including women and children.
Value: €500 000 to 875 000
Deadline: 30 September 2025
https://tinyurl.com/5f6ftevn

Food Safety Innovation
Issued by: Food Safety for Africa
Focus areas: Innovative solutions addressing the food safety challenges in the African informal sector or enhancing existing solutions
Value: €600 000
Deadline: 30 September 2025
https://tinyurl.com/4yy9jrdd

Transformative Capacity Development Programme
Issued by: European Union, Zimbabwe Human Rights NGO Forum and COSPE
Focus areas: NGOs in Zimbabwe
Value: €10 000 to 60 000
Deadline: 1 October 2025
https://tinyurl.com/2pacarbw

360 Woman Africa Enterprise Fund Women‑in‑Business Grant 2025
Deadline: 5 October 2025 (this is beyond September, but still open from August)
Apply: https://grantsdatabase.org/2025/09/08/360‑woman‑africa‑enterprise‑fund‑women‑in‑business‑grant‑2025/

Gauteng NPO Call for Proposals 2026/7
Issued by: Gauteng Department of Social Development
Focus areas: NGOs in Gauteng, South Africa
Value: Not specified
Deadline: 15 October 2025
https://tinyurl.com/ycxxanxd

Strengthening Global Worker Power
Issued by: Democracy at Work Fund
Focus areas: Frontline organisations building resilience and the capacity of workers’ organizations
Value: US$10 000 to 80 000 per grant
Deadline: 27 October 2025
https://tinyurl.com/2v3ywrrf

Preventing Violent Extremism in Somalia
Issued by: Global Community Engagement and Resilience Fund
Focus areas: Strengthening reconciliation and conflict-prevention mechanisms, expanding socio-economic opportunities for young people and women, promoting positive messaging, and enhancing the role of religious leaders in preventing violent extremism
Value: Up to US$1 million over a period of 24 to 28 months
Deadline: 31 October 2025
https://tinyurl.com/4np2wnfc